[HTML][HTML] Controlling amyloid β-peptide fibril formation with protease-stable ligands
LO Tjernberg, C Lilliehöök, DJE Callaway… - Journal of Biological …, 1997 - ASBMB
We have previously shown that short peptides incorporating the sequence KLVFF can bind
to the∼ 40amino acid residue Alzheimer amyloid β-peptide (Aβ) and disrupt amyloid fibril
formation (Tjernberg, LO, Näslund, J., Lindqvist, F., Johansson, J., Karlström, AR,
Thyberg, J., Terenius, L., and Nordstedt, C.(1996) J. Biol. Chem. 271, 8545–8548). Here, it is
shown that KLVFF binds stereospecifically to the homologous sequence in Aβ (ie Aβ 16–
20). Molecular modeling suggests that association of the two homologous sequences leads …
to the∼ 40amino acid residue Alzheimer amyloid β-peptide (Aβ) and disrupt amyloid fibril
formation (Tjernberg, LO, Näslund, J., Lindqvist, F., Johansson, J., Karlström, AR,
Thyberg, J., Terenius, L., and Nordstedt, C.(1996) J. Biol. Chem. 271, 8545–8548). Here, it is
shown that KLVFF binds stereospecifically to the homologous sequence in Aβ (ie Aβ 16–
20). Molecular modeling suggests that association of the two homologous sequences leads …
