Urease-independent chemotactic responses of Helicobacter pylori to urea, urease inhibitors, and sodium bicarbonate
T Mizote, H Yoshiyama, T Nakazawa - Infection and immunity, 1997 - Am Soc Microbiol
T Mizote, H Yoshiyama, T Nakazawa
Infection and immunity, 1997•Am Soc MicrobiolHelicobacter pylori CPY3401 and an isogenic urease-negative mutant, HPT73, showed
chemotactic responses to urea, flurofamide (a potent urease inhibitor), and sodium
bicarbonate. Since urea and sodium bicarbonate are secreted through the gastric epithelial
surface and hydrolysis of urea by urease on the bacterial surface is essential for
colonization, the chemotactic response of H. pylori may be crucial for its colonization and
persistence in the stomach.
chemotactic responses to urea, flurofamide (a potent urease inhibitor), and sodium
bicarbonate. Since urea and sodium bicarbonate are secreted through the gastric epithelial
surface and hydrolysis of urea by urease on the bacterial surface is essential for
colonization, the chemotactic response of H. pylori may be crucial for its colonization and
persistence in the stomach.
Helicobacter pylori CPY3401 and an isogenic urease-negative mutant, HPT73, showed chemotactic responses to urea, flurofamide (a potent urease inhibitor), and sodium bicarbonate. Since urea and sodium bicarbonate are secreted through the gastric epithelial surface and hydrolysis of urea by urease on the bacterial surface is essential for colonization, the chemotactic response of H. pylori may be crucial for its colonization and persistence in the stomach.
American Society for Microbiology