Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing triadin 1
U Kirchhefer, J Neumann, HA Baba, F Begrow… - Journal of Biological …, 2001 - ASBMB
Triadin 1 is a major transmembrane protein in cardiac junctional sarcoplasmic reticulum
(SR), which forms a quaternary complex with the ryanodine receptor (Ca 2+ release
channel), junctin, and calsequestrin. To better understand the role of triadin 1 in excitation-
contraction coupling in the heart, we generated transgenic mice with targeted
overexpression of triadin 1 to mouse atrium and ventricle, employing the α-myosin heavy
chain promoter to drive protein expression. The protein was overexpressed 5-fold in mouse …
(SR), which forms a quaternary complex with the ryanodine receptor (Ca 2+ release
channel), junctin, and calsequestrin. To better understand the role of triadin 1 in excitation-
contraction coupling in the heart, we generated transgenic mice with targeted
overexpression of triadin 1 to mouse atrium and ventricle, employing the α-myosin heavy
chain promoter to drive protein expression. The protein was overexpressed 5-fold in mouse …
