Baseline intestinal absorption and synthesis of cholesterol regulate its response to hypolipidaemic treatments in coronary patients
H Gylling, TA Miettinen - Atherosclerosis, 2002 - Elsevier
Baseline cholesterol metabolism was hypothesized to regulate responses of cholesterol
synthesis and absorption, and serum cholesterol lowering to hypolipidaemic treatment.
Thus, serum cholesterol and non-cholesterol sterols were measured before and during long-
term simvastatin treatment (inhibition of cholesterol synthesis) and subsequent combination
of statin with plant stanol ester margarine (inhibition of cholesterol absorption) consumption
in subjects with low (n= 15) and high (n= 15) absorption of cholesterol, defined by respective …
synthesis and absorption, and serum cholesterol lowering to hypolipidaemic treatment.
Thus, serum cholesterol and non-cholesterol sterols were measured before and during long-
term simvastatin treatment (inhibition of cholesterol synthesis) and subsequent combination
of statin with plant stanol ester margarine (inhibition of cholesterol absorption) consumption
in subjects with low (n= 15) and high (n= 15) absorption of cholesterol, defined by respective …