Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina
K Adachi, Y Fujita, C Morizane, A Akaike… - European journal of …, 1998 - Elsevier
K Adachi, Y Fujita, C Morizane, A Akaike, M Ueda, M Satoh, H Masai, S Kashii, Y Honda
European journal of pharmacology, 1998•ElsevierThis study was performed to examine the roles of body temperature, NMDA receptors and
nitric oxide (NO) synthase in post-ischemic retinal injury in rats. Cell loss in the ganglion cell
layer and thinning of the inner plexiform layer were observed 7 days after ischemia. Cell loss
in the ganglion cell layer but not thinning of the inner plexiform layer was reduced by
hypothermia during ischemia. Intravenous injection of dizocilpine (MK-801) or Nω-nitro-l-
arginine methyl ester (l-NAME) prior to ischemia ameliorated retinal injury. These results …
nitric oxide (NO) synthase in post-ischemic retinal injury in rats. Cell loss in the ganglion cell
layer and thinning of the inner plexiform layer were observed 7 days after ischemia. Cell loss
in the ganglion cell layer but not thinning of the inner plexiform layer was reduced by
hypothermia during ischemia. Intravenous injection of dizocilpine (MK-801) or Nω-nitro-l-
arginine methyl ester (l-NAME) prior to ischemia ameliorated retinal injury. These results …
This study was performed to examine the roles of body temperature, NMDA receptors and nitric oxide (NO) synthase in post-ischemic retinal injury in rats. Cell loss in the ganglion cell layer and thinning of the inner plexiform layer were observed 7 days after ischemia. Cell loss in the ganglion cell layer but not thinning of the inner plexiform layer was reduced by hypothermia during ischemia. Intravenous injection of dizocilpine (MK-801) or Nω-nitro-l-arginine methyl ester (l-NAME) prior to ischemia ameliorated retinal injury. These results suggest that activation of NO synthase following NMDA receptor stimulation is involved in ischemia-induced retinal injury.
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