Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen beta and gamma chains.
T Koyama, LR Hall, WG Haser… - Proceedings of the …, 1987 - National Acad Sciences
T Koyama, LR Hall, WG Haser, S Tonegawa, H Saito
Proceedings of the National Academy of Sciences, 1987•National Acad SciencesUsing a subtractive cDNA cloning method, we isolated a number of T-lymphocyte-specific
genes. One of these genes, represented by the cDNA clone pT49, is expressed in cytotoxic
T lymphocytes but not in helper T lymphocytes or B lymphocytes. The protein structure
deduced from the nucleotide sequence showed a high degree of homology to fibrinogen
beta and gamma subunits. This might indicate that evolutionarily fibrinogen has its origin in
lymphocytes. In spite of the strong homology of pT49 protein to the fibrinogen subunits, the …
genes. One of these genes, represented by the cDNA clone pT49, is expressed in cytotoxic
T lymphocytes but not in helper T lymphocytes or B lymphocytes. The protein structure
deduced from the nucleotide sequence showed a high degree of homology to fibrinogen
beta and gamma subunits. This might indicate that evolutionarily fibrinogen has its origin in
lymphocytes. In spite of the strong homology of pT49 protein to the fibrinogen subunits, the …
Using a subtractive cDNA cloning method, we isolated a number of T-lymphocyte-specific genes. One of these genes, represented by the cDNA clone pT49, is expressed in cytotoxic T lymphocytes but not in helper T lymphocytes or B lymphocytes. The protein structure deduced from the nucleotide sequence showed a high degree of homology to fibrinogen beta and gamma subunits. This might indicate that evolutionarily fibrinogen has its origin in lymphocytes. In spite of the strong homology of pT49 protein to the fibrinogen subunits, the positions of the introns in the pT49 gene are totally different from those of the fibrinogen genes.
National Acad Sciences
