Human polymorphonuclear leukocyte response to Pseudomonas aeruginosa grown in biofilms

ET Jensen, A Kharazmi, K Lam… - Infection and …, 1990 - Am Soc Microbiol
ET Jensen, A Kharazmi, K Lam, JW Costerton, N Høiby
Infection and immunity, 1990Am Soc Microbiol
The interaction of human neutrophils with Pseudomonas aeruginosa biofilms was examined
by using a chemiluminescence assay. The biofilms induced an oxidative burst response by
polymorphonuclear leukocytes which was slow and only 25% of the response to planktonic
bacteria. The reduced response to P. aeruginosa biofilms could play a role in the
persistence of bacteria in chronic infections.
The interaction of human neutrophils with Pseudomonas aeruginosa biofilms was examined by using a chemiluminescence assay. The biofilms induced an oxidative burst response by polymorphonuclear leukocytes which was slow and only 25% of the response to planktonic bacteria. The reduced response to P. aeruginosa biofilms could play a role in the persistence of bacteria in chronic infections.
American Society for Microbiology