Interendothelial junctions: structure, signalling and functional roles
MG Lampugnani, E Dejana - Current opinion in cell biology, 1997 - Elsevier
MG Lampugnani, E Dejana
Current opinion in cell biology, 1997•ElsevierEndothelial cell—cell adhesive junctions are formed by transmembrane adhesive proteins
linked to a complex cytoskeletal network. These structures are important not only for
maintaining adhesion between endothelial cells and, as a consequence, for the control of
vascular permeability, but also for intracellular signalling properties. The establishment of
intercellular junctions might affect the endothelial functional phenotype by the
downregulation or upregulation of endothelial-specific activities.
linked to a complex cytoskeletal network. These structures are important not only for
maintaining adhesion between endothelial cells and, as a consequence, for the control of
vascular permeability, but also for intracellular signalling properties. The establishment of
intercellular junctions might affect the endothelial functional phenotype by the
downregulation or upregulation of endothelial-specific activities.
Endothelial cell—cell adhesive junctions are formed by transmembrane adhesive proteins linked to a complex cytoskeletal network. These structures are important not only for maintaining adhesion between endothelial cells and, as a consequence, for the control of vascular permeability, but also for intracellular signalling properties. The establishment of intercellular junctions might affect the endothelial functional phenotype by the downregulation or upregulation of endothelial-specific activities.
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