A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases
LA Quilliam, JF Rebhun, AF Castro - 2002 - Elsevier
GTPases of the Ras subfamily regulate a diverse array of cellular-signaling pathways,
coupling extracellular signals to the intracellular response machinery. Guanine nucleotide
exchange factors (GEFs) are primarily responsible for linking cell-surface receptors to Ras
protein activation. They do this by catalyzing the dissociation of GDP from the inactive Ras
proteins. GTP can then bind and induce a conformational change that permits interaction
with downstream effectors. Over the past 5 years, approximately 20 novel Ras-family GEFs …
coupling extracellular signals to the intracellular response machinery. Guanine nucleotide
exchange factors (GEFs) are primarily responsible for linking cell-surface receptors to Ras
protein activation. They do this by catalyzing the dissociation of GDP from the inactive Ras
proteins. GTP can then bind and induce a conformational change that permits interaction
with downstream effectors. Over the past 5 years, approximately 20 novel Ras-family GEFs …