Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging
D Ilver, A Arnqvist, J Ogren, IM Frick, D Kersulyte… - Science, 1998 - science.org
Science, 1998•science.org
The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial
adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b
(Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor
activity–directed affinity tagging. The bacterial Leb-binding phenotype was associated with
the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine
strategy based on the BabA adhesin might serve as a means to target the virulent type I …
adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b
(Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor
activity–directed affinity tagging. The bacterial Leb-binding phenotype was associated with
the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine
strategy based on the BabA adhesin might serve as a means to target the virulent type I …
The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity–directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates ofH. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains ofH. pylori.
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