Recurrence of the acute HIV syndrome after interruption of antiretroviral therapy in a patient with chronic HIV infection: a case report
JM Kilby, PA Goepfert, AP Miller… - Annals of internal …, 2000 - acpjournals.org
JM Kilby, PA Goepfert, AP Miller, JW Gnann Jr, M Sillers, MS Saag, RP Bucy
Annals of internal medicine, 2000•acpjournals.orgBackground: Clinical and virologic consequences of temporary interruption of HIV therapy
are incompletely understood. Objective: To describe a febrile illness that was consistent with
the acute HIV syndrome and occurred after interruption of antiretroviral therapy. Design:
Case report. Setting: University clinic. Patient: HIV-infected man. Measurements: Plasma
viral load, lymphocyte subsets, diagnostic evaluation (including cultures and serologic tests),
and analysis of lymph node tissue. Results: The patient began antiretroviral therapy 3 …
are incompletely understood. Objective: To describe a febrile illness that was consistent with
the acute HIV syndrome and occurred after interruption of antiretroviral therapy. Design:
Case report. Setting: University clinic. Patient: HIV-infected man. Measurements: Plasma
viral load, lymphocyte subsets, diagnostic evaluation (including cultures and serologic tests),
and analysis of lymph node tissue. Results: The patient began antiretroviral therapy 3 …
Background
Clinical and virologic consequences of temporary interruption of HIV therapy are incompletely understood.
Objective
To describe a febrile illness that was consistent with the acute HIV syndrome and occurred after interruption of antiretroviral therapy.
Design
Case report.
Setting
University clinic.
Patient
HIV-infected man.
Measurements
Plasma viral load, lymphocyte subsets, diagnostic evaluation (including cultures and serologic tests), and analysis of lymph node tissue.
Results
The patient began antiretroviral therapy 3 months after initial HIV exposure and had sustained viral suppression, except during a brief scheduled treatment interruption. One hundred sixty-nine days after resuming therapy, the patient discontinued it again immediately following an influenza vaccination. Eleven days later, he presented with a febrile mononucleosis-like syndrome associated with dramatic shifts in plasma HIV RNA level (<50 to >1 000 000 copies/mL) and CD4 cell count (0.743 × 109 cells/L to 0.086 × 109 cells/L). Evaluation for alternative causes of fever was unrevealing. Symptoms resolved rapidly with resumption of HIV therapy.
Conclusion
Therapeutic interruption may be associated with profound viral rebound and recurrence of the acute HIV syndrome.
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