Relative susceptibility of SJL/J and B10. S mice to experimental allergic encephalomyelitis is correlated with high and low responsiveness to myelin basic protein
TA Binder, RB Clark, I Goldschneider - Journal of neuroimmunology, 1991 - Elsevier
SJL/J mice are highly susceptible to actively induced experimental allergic
encephalomyelitis (EAE), whereas B10. S mice are not. Yet both strains share the H-2 s
major histocompatibility complex (MHC) haplotype. In order to help determine the cellular
basis for the disparate susceptibility to EAE, the antigen-specific in vitro proliferative
responses of lymph node (LN) T cells from SJL/J and B10. S mice primed with porcine
myelin basic protein (MBP) were assessed. The results indicated that SJL/J mice were high …
encephalomyelitis (EAE), whereas B10. S mice are not. Yet both strains share the H-2 s
major histocompatibility complex (MHC) haplotype. In order to help determine the cellular
basis for the disparate susceptibility to EAE, the antigen-specific in vitro proliferative
responses of lymph node (LN) T cells from SJL/J and B10. S mice primed with porcine
myelin basic protein (MBP) were assessed. The results indicated that SJL/J mice were high …
