Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts
E Song, N Ouyang, M Hörbelt, B Antus, M Wang… - Cellular …, 2000 - Elsevier
Activated macrophages regulate fibrogenesis by providing cytokines and growth factors that
modulate the proliferation and collagen synthesis of fibroblasts. However, macrophages can
be activated in a classical pathway induced by LPS or IFN-γ and an alternative pathway
induced by IL-4 or glucocorticoid. Differently activated macrophages display distinct
biological features. To clarify the difference between these two subsets of macrophages in
the regulatory mechanisms controlling fibrogenesis, human peripheral blood monocytes …
modulate the proliferation and collagen synthesis of fibroblasts. However, macrophages can
be activated in a classical pathway induced by LPS or IFN-γ and an alternative pathway
induced by IL-4 or glucocorticoid. Differently activated macrophages display distinct
biological features. To clarify the difference between these two subsets of macrophages in
the regulatory mechanisms controlling fibrogenesis, human peripheral blood monocytes …