[HTML][HTML] Airway epithelium is the primary target of allograft rejection in murine obliterative airway disease
FG Fernández, A Jaramillo, C Chen, DZ Liu… - American Journal of …, 2004 - Elsevier
Murine heterotopic tracheal allografts develop obliterative airway disease (OAD), a suitable
model of chronic lung allograft rejection. This model, however, fails to account for the
behavior of the allograft when adjacent to recipient airway tissues, particularly the
epithelium. This study was performed to determine the immunologic role of the epithelium in
development of OAD. BALB/c (H2 d) tracheal allografts were transplanted orthotopically into
C57BL/6 (H2 b) mice and harvested 14–150 days post-transplantation. The phenotype of …
model of chronic lung allograft rejection. This model, however, fails to account for the
behavior of the allograft when adjacent to recipient airway tissues, particularly the
epithelium. This study was performed to determine the immunologic role of the epithelium in
development of OAD. BALB/c (H2 d) tracheal allografts were transplanted orthotopically into
C57BL/6 (H2 b) mice and harvested 14–150 days post-transplantation. The phenotype of …