A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions
M Adiels, C Packard, MJ Caslake, P Stewart… - Journal of lipid …, 2005 - ASBMB
The use of stable isotopes in conjunction with compartmental modeling analysis has greatly
facilitated studies of the metabolism of the apolipoprotein B (apoB)-containing lipoproteins in
humans. The aim of this study was to develop a multicompartment model that allows us to
simultaneously determine the kinetics of apoB and triglyceride (TG) in VLDL 1 and VLDL 2
after a bolus injection of [2 H 3] leucine and [2 H 5] glycerol and to follow the catabolism and
transfer of the lipoprotein particles. Here, we describe the model and present the results of …
facilitated studies of the metabolism of the apolipoprotein B (apoB)-containing lipoproteins in
humans. The aim of this study was to develop a multicompartment model that allows us to
simultaneously determine the kinetics of apoB and triglyceride (TG) in VLDL 1 and VLDL 2
after a bolus injection of [2 H 3] leucine and [2 H 5] glycerol and to follow the catabolism and
transfer of the lipoprotein particles. Here, we describe the model and present the results of …
