Thiazolidinediones enhance insulin-mediated suppression of fatty acid flux in type 2 diabetes mellitus
SB Racette, AO Davis, JB McGill… - Metabolism-Clinical …, 2002 - metabolismjournal.com
Type 2 diabetes mellitus is characterized by insulin-resistant glucose and lipid metabolism.
Thiazolidinediones (TZDs) enhance insulin-mediated glucose disposal, but their effects on
lipid kinetics are unknown. We evaluated the effect of the TZD troglitazone on insulin-
mediated suppression of fatty acid and glycerol kinetics. Eight obese men and women (body
mass index [BMI], 34.1 [plusmn] 2.3 kg/m 2) with insulin-requiring type 2 diabetes were
studied before and after 12 weeks of troglitazone therapy (400 mg/d). Whole-body and …
Thiazolidinediones (TZDs) enhance insulin-mediated glucose disposal, but their effects on
lipid kinetics are unknown. We evaluated the effect of the TZD troglitazone on insulin-
mediated suppression of fatty acid and glycerol kinetics. Eight obese men and women (body
mass index [BMI], 34.1 [plusmn] 2.3 kg/m 2) with insulin-requiring type 2 diabetes were
studied before and after 12 weeks of troglitazone therapy (400 mg/d). Whole-body and …
