[HTML][HTML] Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1
ATP binding cassette transporter A1 (ABCA1) is a widely expressed lipid transporter
essential for the generation of HDL. ABCA1 is particularly abundant in the liver, suggesting
that the liver may play a major role in HDL homeostasis. To determine how hepatic ABCA1
affects plasma HDL cholesterol levels, we treated mice with an adenovirus (Ad)-expressing
human ABCA1 under the control of the cytomegalovirus promoter. Treated mice showed a
dose-dependent increase in hepatic ABCA1 protein, ranging from 1.2-fold to 8.3-fold using …
essential for the generation of HDL. ABCA1 is particularly abundant in the liver, suggesting
that the liver may play a major role in HDL homeostasis. To determine how hepatic ABCA1
affects plasma HDL cholesterol levels, we treated mice with an adenovirus (Ad)-expressing
human ABCA1 under the control of the cytomegalovirus promoter. Treated mice showed a
dose-dependent increase in hepatic ABCA1 protein, ranging from 1.2-fold to 8.3-fold using …
