Lecithin: cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice
JW Furbee, JK Sawyer, JS Parks - Journal of Biological Chemistry, 2002 - ASBMB
The purpose of the present study was to test the hypothesis that lecithin: cholesterol
acyltransferase (LCAT) deficiency would accelerate atherosclerosis development in low
density lipoprotein (LDL) receptor (LDLr−/−) and apoE (apoE−/−) knockout mice. After 16
weeks of atherogenic diet (0.1% cholesterol, 10% calories from palm oil) consumption,
LDLr−/− LCAT−/− double knockout mice, compared with LDLr−/− mice, had similar plasma
concentrations of free (FC), esterified (EC), and apoB lipoprotein cholesterol, increased …
acyltransferase (LCAT) deficiency would accelerate atherosclerosis development in low
density lipoprotein (LDL) receptor (LDLr−/−) and apoE (apoE−/−) knockout mice. After 16
weeks of atherogenic diet (0.1% cholesterol, 10% calories from palm oil) consumption,
LDLr−/− LCAT−/− double knockout mice, compared with LDLr−/− mice, had similar plasma
concentrations of free (FC), esterified (EC), and apoB lipoprotein cholesterol, increased …
