An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study
P Sundstrom, P Juto, G Wadell, G Hallmans… - Neurology, 2004 - AAN Enterprises
P Sundstrom, P Juto, G Wadell, G Hallmans, A Svenningsson, L Nystrom, J Dillner…
Neurology, 2004•AAN EnterprisesObjective: To investigate the association between human herpesviruses and multiple
sclerosis (MS), as well as between measles virus and MS. Methods: The authors identified
prospectively collected serum samples from 73 MS cases and retrospective sera from 161
MS cases in two population-based serum bank registers. Analyses of IgG antibody
responses in cases and matched referents were performed for Epstein-Barr virus (EBV
[EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella …
sclerosis (MS), as well as between measles virus and MS. Methods: The authors identified
prospectively collected serum samples from 73 MS cases and retrospective sera from 161
MS cases in two population-based serum bank registers. Analyses of IgG antibody
responses in cases and matched referents were performed for Epstein-Barr virus (EBV
[EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella …
Objective: To investigate the association between human herpesviruses and multiple sclerosis (MS), as well as between measles virus and MS.
Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles.
Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly (borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles.
Conclusion: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset.
American Academy of Neurology