MicroRNAs in vertebrate development
BD Harfe - Current opinion in genetics & development, 2005 - Elsevier
Current opinion in genetics & development, 2005•Elsevier
The vertebrate genome contains hundreds of small non-coding 'microRNAs' that have been
implicated in controlling the expression of potentially thousands of target genes. Presently,
only a handful of these targets have been characterized. Recent reports of microRNA
'sensors', microRNA microarrays and the creation of vertebrates that lack all microRNA
activity will aid in determining the roles played by microRNAs, and the genes that they
regulate, during vertebrate development.
implicated in controlling the expression of potentially thousands of target genes. Presently,
only a handful of these targets have been characterized. Recent reports of microRNA
'sensors', microRNA microarrays and the creation of vertebrates that lack all microRNA
activity will aid in determining the roles played by microRNAs, and the genes that they
regulate, during vertebrate development.
The vertebrate genome contains hundreds of small non-coding ‘microRNAs’ that have been implicated in controlling the expression of potentially thousands of target genes. Presently, only a handful of these targets have been characterized. Recent reports of microRNA ‘sensors’, microRNA microarrays and the creation of vertebrates that lack all microRNA activity will aid in determining the roles played by microRNAs, and the genes that they regulate, during vertebrate development.
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