Requirement of estrogen receptor-α in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk
DM Klotz, SC Hewitt, P Ciana, M Raviscioni… - Journal of Biological …, 2002 - ASBMB
In the uterus insulin-like growth factor-1 (IGF-1) signaling can be initiated by estradiol acting
through its nuclear receptor (estrogen receptor (ER)) to stimulate the local synthesis of IGF-
1. Conversely, in vitro studies have demonstrated that estradiol-independent ER
transcriptional activity can be induced by IGF-1 signaling, providing evidence for a cross-talk
mechanism between IGF-1 and ER. To investigate whether ERα is required for uterine
responses to IGF-1 in vivo, both wild-type (WT) and ERα knockout (αERKO) mice were …
through its nuclear receptor (estrogen receptor (ER)) to stimulate the local synthesis of IGF-
1. Conversely, in vitro studies have demonstrated that estradiol-independent ER
transcriptional activity can be induced by IGF-1 signaling, providing evidence for a cross-talk
mechanism between IGF-1 and ER. To investigate whether ERα is required for uterine
responses to IGF-1 in vivo, both wild-type (WT) and ERα knockout (αERKO) mice were …
