Differential recovery of prostacyclin synthesis in cultured vascular endothelial vs. smooth muscle cells after inactivation of cyclooxygenase with aspirin
TT Hla, JM Bailey - Prostaglandins, leukotrienes and essential fatty acids, 1989 - Elsevier
Conflicting findings from clinical trials on the use of aspirin in preventing myocardial
infarction emphasize the importance of understanding the effects of aspirin on vascular cells.
Cultured vascular endothelial cells and smooth muscle cells of human, rat and bovine origin
synthesized prostacyclin, a key component in vascular homeostasis, when superfused with
14 C arachidonic acid. Prostacyclin synthesis was inactivated following brief treatment with
aspirin, which irreversibly acetylates cyclooxygenase. Marked differences were observed …
infarction emphasize the importance of understanding the effects of aspirin on vascular cells.
Cultured vascular endothelial cells and smooth muscle cells of human, rat and bovine origin
synthesized prostacyclin, a key component in vascular homeostasis, when superfused with
14 C arachidonic acid. Prostacyclin synthesis was inactivated following brief treatment with
aspirin, which irreversibly acetylates cyclooxygenase. Marked differences were observed …
