Sex dimorphisms in the neuroprotective effects of estrogen in an animal model of Parkinson's disease
GE Gillies, HE Murray, D Dexter, S McArthur - … Biochemistry and Behavior, 2004 - Elsevier
The incidence of certain neurological disorders, including Parkinson's disease, appears to
be more prevalent in men. Studies involving estrogen treatment of ovariectomised rodents
attribute this largely to the neuroprotective effects of estrogen. However, a neuroprotective
role for physiological levels of circulating hormones in males and females is less clear.
Using the 6-hydroxydopamine (6-OHDA) model of Parkinson's disease to lesion the
nigrostriatal dopaminergic (NSDA) pathway, we have shown that in females, endogenously …
be more prevalent in men. Studies involving estrogen treatment of ovariectomised rodents
attribute this largely to the neuroprotective effects of estrogen. However, a neuroprotective
role for physiological levels of circulating hormones in males and females is less clear.
Using the 6-hydroxydopamine (6-OHDA) model of Parkinson's disease to lesion the
nigrostriatal dopaminergic (NSDA) pathway, we have shown that in females, endogenously …
