Insulin-like growth factor-I prevents apoptosis in sympathetic neurons exposed to high glucose

JW Russell, EL Feldman - Hormone and metabolic research, 1999 - thieme-connect.com
JW Russell, EL Feldman
Hormone and metabolic research, 1999thieme-connect.com
Diabetic autonomic neuropathy is a common complicationof diabetes, and is present in up to
40% of insulin-dependent dia-betic patients [1]. While the pathogenesis of diabetic auto-
nomic neuropathy remains unknown [2], the Diabetes Control and Complications Trial
(DCCT) indicates that hyperglycemia is critical in the development of diabetic complications,
in-cluding autonomic neuropathy [3—5]. The risk of cardiorespiratory arrest due to
autonomic neuropathy is increased in diabetic patients [1], and 5-year mortality from postural …
Diabetic autonomic neuropathy is a common complicationof diabetes, and is present in up to 40% of insulin-dependent dia-betic patients [1]. While the pathogenesis of diabetic auto-nomic neuropathy remains unknown [2], the Diabetes Control and Complications Trial (DCCT) indicates that hyperglycemia is critical in the development of diabetic complications, in-cluding autonomic neuropathy [3—5]. The risk of cardiorespiratory arrest due to autonomic neuropathy is increased in diabetic patients [1], and 5-year mortality from postural hypotension due to sympathetic dysfunction approaches 60%[1].
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