Male sterility in mice lacking retinoic acid receptor α involves specific abnormalities in spermiogenesis
SSW Chung, X Wang, DJ Wolgemuth - Differentiation, 2005 - Elsevier
The severe degeneration of the germinal epithelium and subsequent male sterility observed
in mice null for the retinoic acid receptor α (RARα) gene suggested its critical role in
spermatogenesis, although the etiology and progression of these abnormalities remain to be
determined. Previous studies have revealed that elongated spermatids in RARα−/− testes
were improperly aligned at the tubular lumen and did not undergo spermiation at stage VIII*.
We now report a distinctive failure of step 8–9 spermatids to orient properly with regard to …
in mice null for the retinoic acid receptor α (RARα) gene suggested its critical role in
spermatogenesis, although the etiology and progression of these abnormalities remain to be
determined. Previous studies have revealed that elongated spermatids in RARα−/− testes
were improperly aligned at the tubular lumen and did not undergo spermiation at stage VIII*.
We now report a distinctive failure of step 8–9 spermatids to orient properly with regard to …
