Keratins represent the most abundant proteins in the epidermis and are mechanical
integrators of space [1]. It has been proposed that a major function of the stratified squamous
epithelial keratins is to impart mechanical strength to cells. Epidermal cells become fragile
after keratin mutations occur and these inherited skin fragility syndrome is now called keratin
disease [1]. In addition, other functions of keratin are discovered. Caulin et al. showed that
normal and malignant epithelial cells deficient in keratin 8 (K8) and K18 were 100 times …