Cytotoxic T cell activity against peptides of Hu protein in anti-Hu syndrome
M Tanaka, Y Maruyama, M Sugie, H Motizuki… - Journal of the …, 2002 - Elsevier
Half of all patients with limbic encephalitis and small cell lung carcinoma (SCLC) have anti-
Hu antibodies that react with all of central and peripheral nervous system neuronal nuclei in
immunohistochemical studies and 35-to 40-kDa reactive bands on western blots of extracts
from isolated central nervous system neurons. The roles of anti-Hu antibodies in neuronal
damage, however, have yet to be shown. Evidence of infiltration of CD8-positive T cells to
tumors and affected nervous tissues and limited use of the T cell receptor repertoire in the …
Hu antibodies that react with all of central and peripheral nervous system neuronal nuclei in
immunohistochemical studies and 35-to 40-kDa reactive bands on western blots of extracts
from isolated central nervous system neurons. The roles of anti-Hu antibodies in neuronal
damage, however, have yet to be shown. Evidence of infiltration of CD8-positive T cells to
tumors and affected nervous tissues and limited use of the T cell receptor repertoire in the …
