The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4+ or CD8+ T cells
J Punnonen, H Yssel, J de Vries - Journal of allergy and clinical …, 1997 - Elsevier
The relative contribution of IL-4 and IL-13 to the regulation of IgE synthesis has remained
relatively poorly characterized, partially because of lack of suitable animal models. We have
studied the roles of IL-4 and IL-13 in human IgE synthesis induced by supernatants derived
from activated CD4++ or CD8+ T cell clones. Neutralizing anti–IL-4 and anti–IL-13
monoclonal antibodies (mAbs) inhibited IgE synthesis induced by anti-CD40 mAbs and
supernatants from CD4+ T cells by an average 61% and 42%, respectively (n= 25) …
relatively poorly characterized, partially because of lack of suitable animal models. We have
studied the roles of IL-4 and IL-13 in human IgE synthesis induced by supernatants derived
from activated CD4++ or CD8+ T cell clones. Neutralizing anti–IL-4 and anti–IL-13
monoclonal antibodies (mAbs) inhibited IgE synthesis induced by anti-CD40 mAbs and
supernatants from CD4+ T cells by an average 61% and 42%, respectively (n= 25) …
