DNA damage in the male germline is associated with poor fertilization rates following IVF,
defective preimplantation embryonic development, and high rates of miscarriage and
morbidity in the offspring, including childhood cancer. This damage is poorly characterized,
but is known to involve hypomethylation of key genes, oxidative base damage,
endonuclease-mediated cleavage and the formation of adducts with xenobiotics and the
products of lipid peroxidation. There are many possible causes of such DNA damage …