The CCR5Δ32 allele is associated with reduced liver inflammation in hepatitis C virus infection
O Wald, O Pappo, ZB Ari, E Azzaria… - European journal of …, 2004 - Wiley Online Library
European journal of immunogenetics, 2004•Wiley Online Library
CCR5Δ32 is a deletion mutation in the chemokine receptor CCR5. Liver inflammatory
activity was found to be significantly reduced (P= 0.005) in Jewish Israeli patients infected
with the hepatitis C virus (HCV) carrying the CCR5Δ32 allele. The CCR5Δ32 allele does not
alter susceptibility to HCV infection; however, it may play a role in the progression and
outcome of the disease.
activity was found to be significantly reduced (P= 0.005) in Jewish Israeli patients infected
with the hepatitis C virus (HCV) carrying the CCR5Δ32 allele. The CCR5Δ32 allele does not
alter susceptibility to HCV infection; however, it may play a role in the progression and
outcome of the disease.
Summary
CCR5Δ32 is a deletion mutation in the chemokine receptor CCR5. Liver inflammatory activity was found to be significantly reduced (P = 0.005) in Jewish Israeli patients infected with the hepatitis C virus (HCV) carrying the CCR5Δ32 allele. The CCR5Δ32 allele does not alter susceptibility to HCV infection; however, it may play a role in the progression and outcome of the disease.
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