Augmentation index in resistance to thyroid hormone (RTH)
PJD Owen, VK Chatterjee, R John… - Clinical …, 2009 - Wiley Online Library
PJD Owen, VK Chatterjee, R John, D Halsall, JH Lazarus
Clinical endocrinology, 2009•Wiley Online LibraryObjective Resistance to thyroid hormone (RTH) is associated with a varied clinical
presentation. The cardiac effects of RTH have been described but vascular function has yet
to be fully evaluated in this condition. We have measured the arterial function of those with
RTH to assess any vascular changes. Design An observational study. Patients Twelve RTH
patients were recruited from the thyroid clinic (mean value±SD), age 40· 8±18· 7 years; BMI
27· 2±4· 2 kg/m2 and compared with 12 healthy, euthyroid, age‐matched controls (age 41 …
presentation. The cardiac effects of RTH have been described but vascular function has yet
to be fully evaluated in this condition. We have measured the arterial function of those with
RTH to assess any vascular changes. Design An observational study. Patients Twelve RTH
patients were recruited from the thyroid clinic (mean value±SD), age 40· 8±18· 7 years; BMI
27· 2±4· 2 kg/m2 and compared with 12 healthy, euthyroid, age‐matched controls (age 41 …
Summary
Objective Resistance to thyroid hormone (RTH) is associated with a varied clinical presentation. The cardiac effects of RTH have been described but vascular function has yet to be fully evaluated in this condition. We have measured the arterial function of those with RTH to assess any vascular changes.
Design An observational study.
Patients Twelve RTH patients were recruited from the thyroid clinic (mean value ± SD), age 40·8 ± 18·7 years; BMI 27·2 ± 4·2 kg/m2 and compared with 12 healthy, euthyroid, age‐matched controls (age 41·4 ± 19·3; BMI 24·8 ± 4·4 kg/m2) with no history of cardiovascular disease. No interventional measures were instituted.
Measurements Arterial stiffness was measured using pulse wave analysis at the radial artery. Thyroid function, fasting lipids and glucose were also measured on the same occasion in both patients and controls.
Results The corrected augmentation index, a surrogate marker of arterial stiffness was significantly higher in patients compared with controls (21·0% ± 14·1%vs. 5·4% ± 18·2%, P < 0·03). Low density lipoprotein cholesterol (LDL‐cholesterol) levels were also significantly elevated in patients compared with controls (3·0 ± 0·6 vs. 2·1 ± 0·5 mmol/l; P < 0·002).
Conclusion RTH patients show evidence in this study of increased augmentation index consistent with an increase in arterial stiffness compared with euthyroid controls. They also demonstrate elevated LDL‐cholesterol levels. Both these measures may lead to increased cardiovascular risk.
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