Lithium's effect in forced-swim test is blood level dependent but not dependent on weight loss
Y Bersudsky, A Shaldubina… - Behavioural …, 2007 - journals.lww.com
The effects of lithium in models of depression are often inconsistent. We aimed to replicate a
regimen that induces robust antidepressant effects in the forced-swim test. Mice were treated
with three different doses of lithium chloride (LiCl) 0.25, 0.4 or 0.5% in food and the forced-
swim test or open field test was performed on day 15. We yoked control mice to food
deprivation to test whether lithium-induced food deprivation could cause the lithium effects in
the forced-swim test. Treatment with LiCl doses leading to blood levels of 1.3 and 1.4 mmol/l …
regimen that induces robust antidepressant effects in the forced-swim test. Mice were treated
with three different doses of lithium chloride (LiCl) 0.25, 0.4 or 0.5% in food and the forced-
swim test or open field test was performed on day 15. We yoked control mice to food
deprivation to test whether lithium-induced food deprivation could cause the lithium effects in
the forced-swim test. Treatment with LiCl doses leading to blood levels of 1.3 and 1.4 mmol/l …
