Genomic and functional characterization of stellate cells isolated from human cirrhotic livers
P Sancho-Bru, R Bataller, X Gasull, J Colmenero… - Journal of …, 2005 - Elsevier
BACKGROUND/AIMS: Hepatic stellate cells (HSCs) are believed to participate in liver
fibrogenesis and portal hypertension. Knowledge on human HSCs is based on studies
using HSCs isolated from normal livers. We investigated the phenotypic, genomic and
functional characteristics of HSCs from human cirrhotic livers. METHODS: HSC were
obtained from normal and cirrhotic human livers. Cells were characterized by
immunocytochemistry and gene microarray analysis. Cell proliferation, Ca2+ changes and …
fibrogenesis and portal hypertension. Knowledge on human HSCs is based on studies
using HSCs isolated from normal livers. We investigated the phenotypic, genomic and
functional characteristics of HSCs from human cirrhotic livers. METHODS: HSC were
obtained from normal and cirrhotic human livers. Cells were characterized by
immunocytochemistry and gene microarray analysis. Cell proliferation, Ca2+ changes and …
