Chronic injury results in a wound healing response that eventually leads to fibrosis. The
response is generalized, with features common among multiple organ systems. In the liver,
various different types of injury lead to fibrogenesis, implying a common pathogenesis.
Although several specific therapies for patients who have different liver diseases have been
successfully developed, including antiviral therapies for those who have hepatitis B and
hepatitis C virus infection, specific and effective antifibrotic therapy remains elusive. Over the …