[HTML][HTML] HDAC1 cooperates with C/EBPα in the inhibition of liver proliferation in old mice
GL Wang, E Salisbury, X Shi, L Timchenko… - Journal of biological …, 2008 - ASBMB
Epigenetic control of liver proliferation involves cooperation between transcription factors
and chromatin-remodeling proteins. In this work, we found that the levels of HDAC1 (histone
deacetylase 1) are increased in quiescent livers of old mice. The elevation of HDAC1 in liver
is mediated by the RNA-binding protein CUGBP1. We found that the age-associated
CUGBP1-eIF2 complex binds to the 5′ region of HDAC1 mRNA and increases translation
of HDAC1 in the liver. Further analyses showed that CUGBP1 also increases expression of …
and chromatin-remodeling proteins. In this work, we found that the levels of HDAC1 (histone
deacetylase 1) are increased in quiescent livers of old mice. The elevation of HDAC1 in liver
is mediated by the RNA-binding protein CUGBP1. We found that the age-associated
CUGBP1-eIF2 complex binds to the 5′ region of HDAC1 mRNA and increases translation
of HDAC1 in the liver. Further analyses showed that CUGBP1 also increases expression of …
