Second passage of a US scrapie agent in cattle
RC Cutlip, JM Miller, HD Lehmkuhl - Journal of comparative pathology, 1997 - Elsevier
Scrapie and bovine spongiform encephalopathy are similar chronic neurodegenerative
diseases of sheep and cattle. An earlier study showed that, on first passage in cattle, a US
scrapie agent caused an encephalopathy that was distinct from bovine spongiform
encephalopathy (BSE). The present report describes a second passage in cattle, carried out
because diseases caused by the spongiform encephalopathy agents often change in
character with additional passages in abnormal hosts. For this work, young calves were …
diseases of sheep and cattle. An earlier study showed that, on first passage in cattle, a US
scrapie agent caused an encephalopathy that was distinct from bovine spongiform
encephalopathy (BSE). The present report describes a second passage in cattle, carried out
because diseases caused by the spongiform encephalopathy agents often change in
character with additional passages in abnormal hosts. For this work, young calves were …
