Immunomodulation in asthma: mechanisms and possible pitfalls
AB Kay - Current opinion in pharmacology, 2003 - Elsevier
Atopic diseases, including atopic asthma, are characterized by T helper cell (Th) 2 cytokine
pathology. The increased prevalence of asthma and allergic diseases, as well as Th1-
associated conditions, is linked to 'excessive'hygiene. Several new immunomodulatory
strategies in asthma and allergy, such as peptide therapy and DNA vaccines, show promise
and are under clinical evaluation. They appear to exert their effects by producing a Th2 to
Th1 shift, as well as inducing regulatory cytokines such as interleukin-10 and transforming …
pathology. The increased prevalence of asthma and allergic diseases, as well as Th1-
associated conditions, is linked to 'excessive'hygiene. Several new immunomodulatory
strategies in asthma and allergy, such as peptide therapy and DNA vaccines, show promise
and are under clinical evaluation. They appear to exert their effects by producing a Th2 to
Th1 shift, as well as inducing regulatory cytokines such as interleukin-10 and transforming …