Lol p I–specific IgE and IgG synthesis by peripheral blood mononuclear cells from atopic subjects in SCID mice
R Gagnon, Y Boutin, J Hébert - Journal of allergy and clinical immunology, 1995 - Elsevier
Background: The development of an animal model representative of the in vivo situation of
human atopic diseases is always of interest for a better understanding of IgE production and
regulation. Along these lines, mice with severe combined immunodeficiency (SCID mice)
engrafted with lymphocytes from atopic subjects might be a suitable model for such studies.
Objective: This study aims to analyze the production of Lol p I–specific IgE and IgG
antibodies in SCID mice after transplantation of human peripheral blood mononuclear cells …
human atopic diseases is always of interest for a better understanding of IgE production and
regulation. Along these lines, mice with severe combined immunodeficiency (SCID mice)
engrafted with lymphocytes from atopic subjects might be a suitable model for such studies.
Objective: This study aims to analyze the production of Lol p I–specific IgE and IgG
antibodies in SCID mice after transplantation of human peripheral blood mononuclear cells …