Anti–T-cell Ig and mucin domain–containing protein 1 antibody decreases TH2 airway inflammation in a mouse model of asthma
JA Encinas, EM Janssen, DB Weiner… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: The T-cell Ig and mucin domain–containing (TIM) gene locus has been
linked to differences in TH2 responsiveness and asthma susceptibility in mice. The
homologous locus in human subjects harbors the gene for TIM-1, which encodes a receptor
for hepatitis A virus and has been linked with decreased susceptibility to atopic disease in
hepatitis A virus–seropositive individuals. OBJECTIVE: We investigated the effects of
administering antibodies against TIM-1 in a mouse model of allergic asthma to determine …
linked to differences in TH2 responsiveness and asthma susceptibility in mice. The
homologous locus in human subjects harbors the gene for TIM-1, which encodes a receptor
for hepatitis A virus and has been linked with decreased susceptibility to atopic disease in
hepatitis A virus–seropositive individuals. OBJECTIVE: We investigated the effects of
administering antibodies against TIM-1 in a mouse model of allergic asthma to determine …