Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants
OBJECTIVES. Our objectives were to identify factors associated with the duration of the first
antibiotic course initiated in the first 3 postnatal days and to assess associations between
the duration of the initial antibiotic course and subsequent necrotizing enterocolitis or death
in extremely low birth weight infants with sterile initial postnatal culture results. METHODS.
We conducted a retrospective cohort analysis of extremely low birth weight infants admitted
to tertiary centers in 1998–2001. We defined initial empirical antibiotic treatment duration as …
antibiotic course initiated in the first 3 postnatal days and to assess associations between
the duration of the initial antibiotic course and subsequent necrotizing enterocolitis or death
in extremely low birth weight infants with sterile initial postnatal culture results. METHODS.
We conducted a retrospective cohort analysis of extremely low birth weight infants admitted
to tertiary centers in 1998–2001. We defined initial empirical antibiotic treatment duration as …
