[HTML][HTML] Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6
Bilirubin, the end product of heme catabolism, is taken up from the blood circulation into the
liver. This work identifies a high-affinity transport protein mediating the uptake of bilirubin
and its conjugates into human hepatocytes. Human embryonic kidney cells (HEK293)
permanently expressing the recombinant organic anion-transporting polypeptide 2 (human
OATP2, also known as LST-1 or OATP-C; symbol SLC21A6) showed uptake of [3 H]
monoglucuronosyl bilirubin,[3 H] bisglucuronosyl bilirubin, and [3 H] sulfobromophthalein …
liver. This work identifies a high-affinity transport protein mediating the uptake of bilirubin
and its conjugates into human hepatocytes. Human embryonic kidney cells (HEK293)
permanently expressing the recombinant organic anion-transporting polypeptide 2 (human
OATP2, also known as LST-1 or OATP-C; symbol SLC21A6) showed uptake of [3 H]
monoglucuronosyl bilirubin,[3 H] bisglucuronosyl bilirubin, and [3 H] sulfobromophthalein …