TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol
B Namer, F Seifert, HO Handwerker, C Maihöfner - Neuroreport, 2005 - journals.lww.com
The aim of this study was to evaluate the psychophysical effects of both TRPA1 and TRPM8
activation in humans by application of either cinnamaldehyde or menthol. We applied 10%
cinnamaldehyde or 40% menthol solutions on the forearm in 10 study participants.
Quantitative sensory testing and laser Doppler imaging was performed before and after
exposure to the compounds. Cinnamaldehyde evoked significant spontaneous pain and
induced heat and mechanical hyperalgesia, cold hypoalgesia and a neurogenic axon reflex …
activation in humans by application of either cinnamaldehyde or menthol. We applied 10%
cinnamaldehyde or 40% menthol solutions on the forearm in 10 study participants.
Quantitative sensory testing and laser Doppler imaging was performed before and after
exposure to the compounds. Cinnamaldehyde evoked significant spontaneous pain and
induced heat and mechanical hyperalgesia, cold hypoalgesia and a neurogenic axon reflex …