Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study
ID Grachev, BE Fredrickson, AV Apkarian - Pain, 2000 - Elsevier
The neurobiology of chronic pain, including chronic back pain, is unknown. Structural
imaging studies of the spine cannot explain all cases of chronic back pain. Functional brain
imaging studies indicate that the brain activation patterns are different between chronic pain
patients and normal subjects, and the thalamus, and prefrontal and cingulate cortices are
involved in some types of chronic pain. Animal models of chronic pain suggest abnormal
spinal cord chemistry. Does chronic pain cause brain chemistry changes? We examined …
imaging studies of the spine cannot explain all cases of chronic back pain. Functional brain
imaging studies indicate that the brain activation patterns are different between chronic pain
patients and normal subjects, and the thalamus, and prefrontal and cingulate cortices are
involved in some types of chronic pain. Animal models of chronic pain suggest abnormal
spinal cord chemistry. Does chronic pain cause brain chemistry changes? We examined …