CONTEXT: The perception of pain due to an acute injury or in clinical pain states undergoes
substantial processing at supraspinal levels. Supraspinal, brain mechanisms are
increasingly recognized as playing a major role in the representation and modulation of pain
experience. These neural mechanisms may then contribute to interindividual variations and
disabilities associated with chronic pain conditions. OBJECTIVE: To systematically review
the literature regarding how activity in diverse brain regions creates and modulates the …