Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain

KB Jensen, E Kosek, F Petzke, S Carville, P Fransson… - PAIN®, 2009 - Elsevier
Over the years, many have viewed Fibromyalgia syndrome (FMS) as a so-called “functional
disorder” and patients have experienced a concomitant lack of interest and legitimacy from
the medical profession. The symptoms have not been explained by peripheral mechanisms
alone nor by specific central nervous system mechanisms. In this study, we objectively
evaluated the cerebral response to individually calibrated pain provocations of a pain-free
body region (thumbnail). The study comprised 16 female FMS patients and 16 individually …