Increased gray matter density in young women with chronic vulvar pain
Provoked vestibulodynia (PVD) is a common form of chronic vulvar pain with unknown
aetiology. Central pain regulatory mechanisms have been suggested to be disrupted in
PVD, and consequently, PVD may be associated with anatomical changes in pain
modulatory brain areas. Here, we compared total gray matter volumes and regional gray
matter densities between 14 medication-free young women with relatively short-standing
PVD (1 to 9 yrs) and 14 control subjects using whole brain voxel-based morphometry (VBM) …
aetiology. Central pain regulatory mechanisms have been suggested to be disrupted in
PVD, and consequently, PVD may be associated with anatomical changes in pain
modulatory brain areas. Here, we compared total gray matter volumes and regional gray
matter densities between 14 medication-free young women with relatively short-standing
PVD (1 to 9 yrs) and 14 control subjects using whole brain voxel-based morphometry (VBM) …