Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients
T Schmidt-Wilcke, E Leinisch, S Gänssbauer… - Pain, 2006 - Elsevier
Although chronic back pain is one of the most frequent reasons for permanent impairment in
people under 65, the neurobiological mechanisms of chronification remain vague. Evidence
suggests that cortical reorganisation, so-called functional plasticity, may play a role in
chronic back pain patients. In the search for the structural counterpart of such functional
changes in the CNS, we examined 18 patients suffering from chronic back pain with voxel-
based morphometry and compared them to 18 sex and age matched healthy controls. We …
people under 65, the neurobiological mechanisms of chronification remain vague. Evidence
suggests that cortical reorganisation, so-called functional plasticity, may play a role in
chronic back pain patients. In the search for the structural counterpart of such functional
changes in the CNS, we examined 18 patients suffering from chronic back pain with voxel-
based morphometry and compared them to 18 sex and age matched healthy controls. We …