Deficiency in endogenous modulation of prolonged heat pain in patients with irritable bowel syndrome and temporomandibular disorder
CD King, F Wong, T Currie, AP Mauderli, RB Fillingim… - PAIN®, 2009 - Elsevier
Females with Irritable Bowel Syndrome (IBS) and Temporomandibular Disorder (TMD) are
characterized by enhanced sensitivity to experimental pain. One possible explanation for
this observation is deficiencies in pain modulation systems such as Diffuse Noxious
Inhibitory Control (DNIC). In a few studies that used brief stimuli, chronic pain patients
demonstrate reduced DNIC. The purpose of this study was to compare sensitivity to
prolonged heat pain and the efficacy of DNIC in controls to IBS and TMD patients. Heat pain …
characterized by enhanced sensitivity to experimental pain. One possible explanation for
this observation is deficiencies in pain modulation systems such as Diffuse Noxious
Inhibitory Control (DNIC). In a few studies that used brief stimuli, chronic pain patients
demonstrate reduced DNIC. The purpose of this study was to compare sensitivity to
prolonged heat pain and the efficacy of DNIC in controls to IBS and TMD patients. Heat pain …