Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats
M Sasaki, H Obata, K Kawahara, S Saito, F Goto - PAIN®, 2006 - Elsevier
Inflammation or injury of peripheral tissue causes release of chemical mediators, including 5-
hydroxytryptamine (5-HT), which is involved in the facilitation of nociceptive transmission
and the induction of hyperalgesia. The present study examined the effect of a selective 5-
HT2A receptor antagonist, sarpogrelate, on hyperalgesia and allodynia induced by thermal
injury in rats. Mild thermal injury to the hindpaw produces thermal hyperalgesia in the
injured area (primary thermal hyperalgesia) and mechanical allodynia in sites adjacent to …
hydroxytryptamine (5-HT), which is involved in the facilitation of nociceptive transmission
and the induction of hyperalgesia. The present study examined the effect of a selective 5-
HT2A receptor antagonist, sarpogrelate, on hyperalgesia and allodynia induced by thermal
injury in rats. Mild thermal injury to the hindpaw produces thermal hyperalgesia in the
injured area (primary thermal hyperalgesia) and mechanical allodynia in sites adjacent to …