Dynamic and static components of mechanical hyperalgesia in human hairy skin

M Koltzenburg, LER Lundberg, EH Torebjörk - Pain, 1992 - journals.lww.com
M Koltzenburg, LER Lundberg, EH Torebjörk
Pain, 1992journals.lww.com
The principle finding of the present study is that there are two types of mechanical
hyperalgesia developing in human hairy skin following injurious stimuli. Mechanical
hyperalgesia comprises a dynamic component (brush-evoked pain, allodynia) signalled by
large myelinated afferents and a static component (hyperalgesia to pressure stimuli)
signalled by unmyelinated afferents. While the static component is only found in the injured
area, the dynamic component also extends into a halo of undamaged tissue surrounding the …
Abstract
: The principle finding of the present study is that there are two types of mechanical hyperalgesia developing in human hairy skin following injurious stimuli. Mechanical hyperalgesia comprises a dynamic component (brush-evoked pain, allodynia) signalled by large myelinated afferents and a static component (hyperalgesia to pressure stimuli) signalled by unmyelinated afferents. While the static component is only found in the injured area, the dynamic component also extends into a halo of undamaged tissue surrounding the injury.
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